Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. kresovich@northwestern.edu. Division of Epidemiology and Biostatisitics, University of Illinois at Chicago School of Public Health, Chicago, IL, 60612, USA. kresovich@northwestern.edu. Division of Epidemiology and Biostatisitics, University of Illinois at Chicago School of Public Health, Chicago, IL, 60612, USA. Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. VA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA. Department of Environmental Health and Program in Quantitative Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. Departments of Epidemiology and Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, NY, 10032, USA.